The Potomac 5500 is a single axle heavy-duty box truck with an enclosed metal cargo compartment that comes in either plain or with logos from various New Bordeaux businesses painted on them.
This vehicle is available from the start of the game and can be found throughout all districts of New Bordeaux.
- The 5500 is driven by Father James to the Warm Hearts Neighborhood Kitchen in The Home Fires Burn.
- A Dixie Mafia variant is used in .45 in My Hand.
- A medical supply version is used in Work the Man Who Bleeds.
- Both Sweetwater Distillery and Roberdeau Meat Packing variants are used in The Blade Stained Red.
- A Cavar Construction version is used in Compromised Corruption.
- The Potomac 5500 is similar in appearance to the 1955 Chevrolet Task-Force 3800.