Pepe Gambino is a soldato in the Gravina Crime Family.
Pepe is a two-bit waste of skin who gets off on beating hookers, but he hangs around Sal Gravina like a bad smell. Jimmy kills him in the mission Trash Trailer in Jimmy's Vendetta.
- His last name is a reference to the real-life Gambino crime family.
- He drives a Lassiter Series 69 and is one of the only known characters to own one in Jimmy's Vendetta.
- His model is used later on for various generic soldati.