This is where the Salieri Crime Family is situated and where most of the game's missions start. The family's base of operations, Salieri's Bar, is located here. The name of this neighborhood comes from the migration of Italians, notably Sicilians, to the United States. The city tramline runs through this area, bypassing Salieri's Bar, connecting Little Italy with Chinatown and the Works Quarter. Also, the elevated railway has two stations here, namely the "Little Italy" station and the "Winslet Avenue" station.