Leo's Cell was Leone Galante's home in Hartmann Federal Penitentiary. After Vito Scaletta killed Brian O'Neill he also began living here. The cell is furnished like a suite and is the result of Leo's rank as Consigliere in the Vinci crime family on the outside.
- A picture of "The Last Supper" by Leonardo DaVinci can be seen in the cell.
- In the final cutscene of the chapter Time Well Spent, Leo, Pepe and Vito can be seen cooking dinner themselves in Leo's cell. This might be a reference to the 1990 Martin Scorsese movie, Goodfellas, where one of the characters Paul Cicero, played by Paul Sorvino, can be seen cooking sausages in a skillet very similar to Leo cooking the spaghetti mixture in his skillet.