Franco "Frank" Vinci arrived in Empire Bay in 1908 along with his closest friend Leone "Leo" Galante. Shortly after his arrival, he immediately set up extortion rackets in the Italian immigrant community. His gang would later rule the city for the next decade. Frank operates discreetly, having close ties with the politicians and police (This is clear by the way Leone "Leo" Galante shortened Vito Scaletta's prison sentence by about four years). When Prohibition cash dried up in the early 30s, tension between the Vinci and Moretti families erupted into full-scale war. This conflict cost Frank his underworld supremacy, but he remains a powerful advocate of traditional mafia values, especially when it comes to drugs.
Vinci's very first appearance is when he attends the ceremony of Vito Scaletta and Joe Barbaro being "made" by the Falcone crime family, offering words of wisdom "stay away from the dope... no dope, that's our policy". Later on during the period that both the Vinci and Falcone families were on thin ice, mainly because the Falcone family trying to whack their Consigliere Leo Galante, and because the Falcone family were breaking the Mafia traditions of no drugs. He has Joe and Vito kidnapped and brought to Empire Bay Construction Co. to have things "explained" to him on the recent situation involving the Empire Bay Triads. After this event, he is never seen again. Though, he was last mentioned when Leo tells Vito that Frank and the rest of the Commission want him (and Joe) dead for the Chinese massacre and the murder of many of the Vinci soldiers at the Southport docks and Empire Bay Construction Co. they had committed in revenge for the murder of Henry Tomasino.
His name may have came from the famous Italian Polymath, Leonardo Da Vinci. Da Vinci was the painter who created the famous "Mona Lisa" in which Frank Vinci owns a restaurant of the same name.
In the "Made Man" scene of Chapter Nine, part of his anti-drug speech is a word for word quote from Marlon Brando's speech from "The Godfather", in which Don Corleone lectures his oldest child, Santino, about the evils of drugs in the "business".