- "Where'd you get all this money from, Vito? You haven't done nothing you'll be sorry for, have you?"
- — Francesca Scaletta
Francesca Scaletta is Vito's older sister. A shy and quiet girl, she graduated from high school with honors and has run the church youth club since she was sixteen. Francesca tried to steer Vito away from the local street gangs when they were young, rewarding him with candy for doing chores and attending church. Now that they're older, all she can do is pray. Francesca, or "Frankie" as Vito calls her, lives at home with her mother, supporting them both with her bookkeeping job at the Trago Oil Co.
In 1945, Francesca visits Vito in jail and tells him that she's getting married to a man named Eric Reilly.
When Francesca's husband Eric abuses her, she goes to Vito to ask him to talk with Eric. Instead, Vito gives Eric a brutal beating. Francesca later calls Vito, and he says he would kill Eric if he ever beats her again. Horrified by this, Francesca tells Vito to stay away from Eric and herself. Her phone call to Vito is the last time Francesca is seen or heard in the game.
- Antonio Scaletta (father, deceased)
- Maria Scaletta (mother, deceased)
- Vito Scaletta (brother)
- Eric Reilly (husband)