Enzo, a former lieutenant in the Carillo Crime Family who had been running Barclay Mills for decades, having gotten his start through an extortion racket at Barclay Railways, sided with Sal Marcano in taking over New Bordeaux's organized crime.
Sammy's death at the hands of the Marcanos causes him to doubt Sal's trust in him, and when Lincoln Clay starts tearing down the Marcano crime family Enzo reluctantly makes a deal with Lincoln to escape.
Enzo asks Lincoln to meet him at the quarry in Barclay Mills, where the two work out a deal for Enzo to go into hiding. The two then escape the quarry in Enzo's Bulworth Mohican, killing and evading Marcano's henchmen, many of whom were once Enzo's underlings, and demolishing the quarry at Enzo's behest to prevent his dynamite from falling into Marcano's hands. Lincoln drops Enzo off at the Carousel Hotel in Delray Hollow, where Enzo apologizes for the death of Sammy.
- He is marked in the Kill List as "escaped" rather than "deceased", making him the only lieutenant to be spared.
- Despite John Donovan telling Lincoln in a cutscene that Enzo is 61 years old, the Kill List states that he is 58 years old.