- Tommy Angelo meets with detective Norman and tells him the story of how he became involved with the Salieri Crime Family.
- They first appear in the beginning of Time Well Spent where three detectives arrest Vito Scaletta for stealing gas stamps in Chapter 3.
- Two can be seen knocking on a door near the Scaletta Apartment in Balls and Beans.
- In Joe's Adventures they appear in the mission Witness - Frozen Memories. Joe Barbaro follows two detectives to the Yacht Club to eliminate the witness, Richie Mazzeo, who was going to testify against the Clemente Crime Family.
- They make small appearances in the Jimmy DLCs.
- Lincoln Clay works with Jim McCormick, a detective with the New Bordeaux Police Department, in taking down Doc Gaston and his drug racket in the French Ward.
- While never mentioned in game, detectives Gabe and Chris from Joe's Adventures are the only two named detectives.
- In the main game they drive a Culver Empire Detective Special, but in Joe's Adventures they drive a Lassiter Series 69.