A Caporegime (or capodecina), commonly known as a Capo, is a high ranking member of a crime family and one of the Don's most trusted allies. A capo (which is Italian for captain) is in charge of a crew called a regime. There are usually four to six crews in each family, possibly even seven to ten crews, each one consisting of up to twenty soldati and associates, though in the past (or in the event of a war) the crew had a larger number of men. Capo's run their own family territory but must follow the limitations and guidelines created by the boss, as well as pay him his cut of their profits. Capos are nominated by the underboss, but typically chosen by the boss himself.
- Derek Pappalardo - Vinci crime family (1933-1951)
- Luca Gurino - Clemente crime family (Unknown-1951)
- Sam - Salieri crime family (Unknown-1938)
- Rocco - Falcone crime family (Unknown-1950)
- Ennio Salieri - Peppone crime family (Unknown-1921)
- Don Morello - Peppone crime family (Unknown-1921)
- Joe was offered the position of Caporegime in the Falcone crime family in Per Aspera Ad Astra if he killed his best friend Vito. However, he refused and assisted Vito in killing a large number of Falcone soldati as well as Carlo Falcone, the head of the Falcone crime family, himself.