Born in 1893, Bruno sits at the top of a network of loan sharks in Empire Bay, and is officially sanctioned by the Commission. He lends mob money to small-time sharks, crooks, and businessmen, charging extortionate rates of interest and backed up by mafia families. He is fair insofar as he treats all debtors equally. He will honor his side of any bargain to the letter, but expects the same in return. Numerous stories exist of those who have failed to pay Bruno back on time. One such story, narrated by Joe, tells of the The Maltese Falcon bathroom attendant, Micky the Crab, who has only a finger and a thumb on one hand. He owed money to Bruno, and it is believed that the two occurrences are related. He has his office in Southport in an alleyway off of Palisade Street.
In 1951, Henry Tomasino along with Joe Barbaro and Vito Scaletta decided to borrow money from Bruno for a drug deal with the Empire Bay Triads. They borrowed $35,000 from him in return for a payment of $55,000 by the end of the week. After they arrived in one of the Triads' fronts the Sea Gift Fishing Co. warehouse and got the drugs, they were ambushed by a group of mysterious gangsters disguised as police officers, they were able to kill them all and successfully distributed the drugs. Life was getting from the better for the three until Carlo Falcone found out about the deal and took a cut from the dealing profit in the amount of $60,000. Henry was later killed by the Triads and they took the rest of the dealing profit. Joe and Vito manage to earn $55,000 and Vito returned the money to Bruno, who was impressed that he managed to get it paid back on time considering that he learned that their heroin enterprise went haywire and was willing to extend credit for such extenuating circumstances. Bruno later reveals that he was the loan shark that Vito's father owed $2,000 to. When Vito expresses annoyance that the debt did not die with his father, rather the harassment expanded to his mother and Francesca, Bruno defends himself by saying he did not force Antonio Scaletta to take his money.
- Bruno Levine bears a resemblance to Frank Colletti, Don Salieri's best friend and consigliere.
- He has an assistant named Isaac.
- Bruno's quote from the Bible is Exodus, Chapter 22, Verse 24. "And my wrath shall wax hot, and I will kill you with the sword; and your wives shall be widows, and your children fatherless."