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An Antagonist, simply put, is an adversary of the hero or protagonist in the game. A game may have several antagonists, some major and some minor, and they may change as the game progresses or the hero changes alliances.

Current list of prominent antagonists

Mafia: The City of Lost Heaven

Don Morello

Don Morello
Don Morello is the head of the Morello Crime Family and Salieri's main adversary; he served as the main antagonist for the first half of the first game's storyline. He attempted to take over all of Salieri's territory and businesses in Lost Heaven, but his greed eventually led to his death and downfall.
Sergio Morello

Sergio Morello Jr.
Sergio Morello is Don Morello's brother and the Underboss of the Morello family. He has connections to the unions in Lost Heaven and is known for his uncanny ability to evade death, making him practically untouchable.
Don Salieri

Don Salieri
Don Salieri is the head of the Salieri Crime Family and former boss of protagonist Thomas Angelo; he is an old type mafioso who heads his family in Little Italy. However, he tends to choose business over friendship, even if it means killing the people he has known for years.
Sam (Mafia)

Sam
Sam is a Caporegime working for the Salieri family who brought protagonist Thomas Angelo into their family and worked with him and Paulie. He is a nice guy, but he would put his loyalty to the family above his friends, even if it means killing them.

Mafia II

Luca Gurino

Luca Gurino
Luca Gurino is the ruthless Capo of the Clemente Crime Family; he is a well known sociopath. His profession is to brutally torture people, which is how he earned his rank in the family.
Brian O'Neill

Brian O'Neill
Brian O'Neill is the leader of the O'Neill Gang, he is known for working as hired muscle, taking care of the dirty works for his clients.
Mickey Desmond

Mickey Desmond
Mickey Desmond became the boss of the O'Neill Gang after the death of his cousin. He will do anything to prove his power, even trying to kill a Falcone soldier, the one who killed his cousin.
Alberto Clemente

Alberto Clemente
Don Alberto Clemente is the head of the Clemente family. He rules his family with an iron fist, striking fear into everyone, including his own men.
Derek Pappalardo

Derek Pappalardo
Derek is the Capo of the Vinci Crime Family; he handles all the import business of the family at the docks. He is very wel known for his slave labor policy for his workers.
Steve Coyne

Steve Coyne
Steve is Derek's Enforcer; he helps run things at the docks and would gladly follow any orders given to him by Derek without any hesitation.
Carlo Falcone

Carlo Falcone
Carlo Falcone is the head of the Falcone Crime Family, who would dare to overstep the boundaries of the Mafia code and run a drug business to boost his profit.

Mafia II DLCs

Eddie Fu

Eddie Fu
Eddie Fu is the leader of the Empire Bay Triads with connections in his pocket, who would dare to cross paths with the Irish Gang, even if it means starting a gang war.
Elroy Tussle

Elroy Tussle
Elroy Tussle is the leader of the Bombers, who is trying to expand his gang in Empire Bay in order to compete against the local Mafia.
Tam Brodie

Tam Brodie
Tam Brodie is Jimmy's former employer and the leader of the Brodie Gang; he wouldn't mind to tie up loose ends, even if it means betraying his own friend.
Sal Gravina

Sal Gravina
Don Sal Gravina is the notorious leader of the Gravina Crime Family; he will not hesitate in getting rid of anyone who stands in his way.
BJ Load Screen 5

Judge Hillwood
Judge Hillwood is the corrupt official of Empire Bay; he associated with local gangs and Mafia families to hold Empire Bay in the palm of his hand.
Rocco

Rocco
Rocco is the Underboss of the Falcone family, appearing only in the DLC Joe's Adventures. He used Joe to cover his tracks from his plan to take over the family.

Mafia III

Sal Marcano

Sal Marcano
Sal Marcano is the head of the Italian mob in New Bordeaux, and the main antagonist in Mafia III.
Giorgi Marcano

Giorgi Marcano
Giorgi Marcano is the son of Sal Marcano and a secondary antagonist in Mafia III.

Mafia III DLCs

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Walter Beaumont

Walter Beaumont
Walter Beaumont is the sheriff of Sinclair Parish and the main antagonist in Faster, Baby!.
Connor Aldridge

Connor Aldridge
Connor Aldridge is an old rival of John Donovan and the main antagonist in Stones Unturned.
Bonnie

Bonnie Harless
Bonnie Harless is the leader of The Ensanglante and the main antagonist in Sign of the Times.

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